American Journal of Psychiatry
The investigators mentions that the reviewers cannot be blinded since the effect of Spavato profoundly impacts the patient's appearance:
“Efficacy Assessments because Esketamine exhibits transient dissociative effects that are difficult to blind,” possibly biasing the site staff supervising the dosing, all MADRS assessments (used for the primary endpoint, the first key secondary endpoint, and calculation of response and remission rates) were performed by independent, remote (by telephone) raters who were blind to the protocol details, including study visit, the patients clinical status, and side effects during the trial”
For the reasons spelled out in a publication for Esketamine/Spavato sponsored by Janssen Pharmaceuticals, we attempted to identify some of the perpetrators of Mass Killing that have facial features indicating they received Esketamine. We collected a series of before and after photos. In some of the photos, we can see by examining the pupils that the perpetrators were treated previously with an SSRI. Ostensibly, these findings should be confirmed.
First Experience Working on Pharmaceutical Cases
In approximately March of 2006, I met Dr. Hersh’s father, an optician in the
men’s room of the building, and he expressed concern that some of his
patients were experiencing severe eye infections called Fusarium Keratitis. As
it turned out, there were patients worldwide experiencing the same illness. It
was an outbreak, and some patients were losing their vision. It was occurring
in 33 different States of the US as well as in Hong Kong and Singapore. New
Jersey had reported three cases to the CDC by March 2006, Chang et al. 2006.